Publications (Selected)

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1. Srivastava S, Panda S, Li Z, Fuhs SR, Hunter T, Thiele DJ, Hubbard SR*, Skolnik EY. eLife doi:10.7554/eLife. 16093 (2016) [PubMed]

Targeting the inactive conformation of JAK2 in hematological malignancies. Silvennoinen O, Hubbard SR. Cancer Cell 28, 1-2 (2015) [PubMed]

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms. Silvennoinen O, Hubbard SR. Blood 125, 3388-3392 (2015) [PubMed]

ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation. Hammarén H, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O. Proc Natl Acad Sci USA 112, 4642-4647 (2015) [PubMed]

The tyrosine kinase domains of the insulin and IGF1 receptors are functional dimers in the activated state. Cabail MZ, Li S, Lemmon E, Bowen ME, Hubbard SR*, Miller WT. Nat Commun 6:6406 doi: 10.1038/ncomms7406 (2015) [PubMed] [4XLV]

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide. Samanovic MI, Tu S, Novák O, Iyer LM, McAllister FE, Aravind L, Gygi SP, Hubbard SR, Strnad M, Darwin KH, Mol Cell 57, 984-994 (2015) [PubMed]

IRAK4 activation: a cautious embrace. Hubbard SR. Mol Cell 55, 805-806 (2014) [PubMed]

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase. Shan Y, Gnanasambandan K, Ungureanu D, Kim ET, Hammaren H, Yamashita K, Silvennoinen O, Shaw DE, Hubbard SR. Nat Struct Mol Biol 21, 579-584 (2014) [PubMed]

Structural basis for the interaction of the adaptor protein Grb14 with activated Ras. Qamra R, Hubbard SR. PLoS ONE 2013 Aug13;8(8):e72473 [PubMed] [4K81]

Insulin meets its receptor. Hubbard SR. Nature 493, 171-172 (2013) [PubMed]

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase. Hubbard SR. Cold Spring Harb Perspect Biol Mar 1;5(3). doi:pii: a008946. 10.1101/cshperspect.a008946 (2013) [PubMed]

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Bandaranayake RM, Ungureanu D, Shan Y, Shaw DE, Silvennoinen O, Hubbard SR. Nat Struct Mol Biol 19, 754-759 (2012) [PubMed] [4FVP] [4FVQ] [4FVR]

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. Wynn JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR*, Philips MR. J Cell Biol 199, 317-329 (2012) [PubMed] [3TCA]

Mycobacterium tuberculosis prokaryotic ubiquitin-like protein (Pup) deconjugating enzyme Dop is an unusual aspartate amidase. Burns KE, McAllister F, Schwerdtfeger C, Mintseris J, Cerda-Maira F, Noens EE, Wilmanns M, Hubbard SR, Melandri F, Ovaa H, Gygi SP, Darwin KH. J Biol Chem 287, 37522-37529 (2012) [PubMed]

Agrin binds to the N-terminal region of Lrp4 and stimulates association between Lrp4 and the first Ig-like domain in MuSK. Zhang W, Coldefy AS, Hubbard SR, Burden SJ. J Biol Chem 286, 40624-40630 (2011) [PubMed]

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O. Nat Struct Mol Biol 18, 971-976 (2011) [PubMed]

Cytokine signaling exposed. Hubbard SR. Structure 19, 1-2 (2011) [PubMed]

Structure-guided identification of a laminin binding site on the laminin receptor precursor. Jamieson KV, Hubbard SR*, Meruelo D. J Mol Biol 405, 24-32 (2011) [PubMed]

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Bergamin E, Hallock PT, Burden SJ, Hubbard SR. Mol Cell 38, 100-109 (2010) [PubMed] [3ML4]

Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis. Cerda-Maira FA, Pearce MJ, Fuortes M, Bishai WR, Hubbard SR, Darwin KH. Mol Microbiol 77, 1123-1135 (2010) [PubMed]

Crystal structure of the Frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. Stiegler AL, Burden SJ, Hubbard SR. J Mol Biol 393, 1-9 (2009) [PubMed] [3HKL]

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Depetris RS, Wu J, Hubbard SR. Nat Struct Mol Biol 16, 833-839 (2009) [PubMed] [3HK0]

The juxtamembrane region of EGFR takes center stage. Hubbard SR. Cell 137, 1181-1183 (2009) [PubMed]

Structure and mechanism of the insulin receptor tyrosine kinase. Hubbard SR. Handbook of Cell Signaling, 2nd Ed (Bradshaw RA & Dennis EA, editors), Ch 45, 307-314 (2009)

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. Wu J, Li W, Craddock BP, Foreman KW, Mulvihill MJ, Ji Q, Miller WT, Hubbard SR. EMBO J 27, 1985-1994 (2008) [PubMed] [3D94]

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Nat Struct Mol Biol 15, 251-258 (2008) [PubMed] [3BU3]

Crystal structure of the human laminin receptor precursor. Jamieson KV, Wu J, Hubbard SR*, Meruelo D. J Biol Chem 283, 3002-3005 (2008) [Pubmed] [3BCH]

Receptor tyrosine kinases: mechanisms of activation and signaling. Hubbard SR, Miller WT. Curr Opin Cell Biol 19, 117-123 (2007) [PubMed]

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. Stiegler AL, Burden SJ, Hubbard SR. J Mol Biol 364, 424-433 (2006) [PubMed] [2IEP]

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Bergamin E, Wu J, Hubbard SR. Structure 14, 1285-1292 (2006) [PubMed] [2HMH]

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Hu J, Hubbard SR. J Mol Biol 361, 69-79 (2006) [PubMed] [2HDV] [2HDX]

EGF receptor activation: push comes to shove. Hubbard SR. Cell 125, 1029-1031 (2006) [PubMed]

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Structure 13, 1643-1651 (2005) [PubMed] [2B4S]

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR. Mol Cell 20, 325-333 (2005) [PubMed] [2AUG] [2AUH]

EGF receptor inhibition: attacks on multiple fronts. Hubbard SR. Cancer Cell 7, 287-288 (2005) [PubMed]

Structural characterization of a novel Cbl phosphotyrosine-recognition motif in the APS family of adapter proteins. Hu J, Hubbard SR. J Biol Chem 280, 18943-18949 (2005) [PubMed] [1YVH]

Juxtamembrane autoinhibition in receptor tyrosine kinases. Hubbard SR. Nat Rev Cell Mol Biol 5, 464-470 (2004) [PubMed]

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. Mol Cell 12, 1379-1389 (2003) [PubMed] [1RPY] [1RQQ]

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor. Li S, Covino ND, Stein EG, Till JH, Hubbard SR. J Biol Chem 278, 26007-26014 (2003) [PubMed] [1P14]

Structural basis for dimerization of the Grb10 SH2 domain: implications for ligand specificity. Stein EG, Ghirlando R, Hubbard SR. J Biol Chem 278, 13257-13264 (2003) [PubMed] [1NRV]

Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR. Structure 10, 1187-1196 (2002) [PubMed] [1LUF]

Structure and autoregulation of the insulin-like growth factor-1 receptor kinase. Favelyukis S, Till JH, Hubbard SR*, Miller WT. Nat Struct Biol 18, 1058-1063 (2001) [PubMed] [1K3A]

Mechanism-based design of a protein kinase inhibitor. Parang K, Till JH, Ablooglu AJ, Kohanski RA, Hubbard SR, Cole PA. Nat Struct Biol 8, 37-41 (2001) [PubMed] [1GAG]

Protein tyrosine kinase structure and function. Hubbard SR, Till JH. Annu Rev Biochem 69, 373-398 (2000) [PubMed]

Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta. Mandiyan V, Andreev J, Schessinger J, Hubbard SR. EMBO J 18, 6890-6898 (1999) [PubMed] [1DCQ]

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, Lu GH, Eliseenkova AV, Green D, Schlessinger J, Hubbard SR. EMBO J 17, 5896-5904 (1998) [PubMed] [2FGI]

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. Hubbard SR. EMBO J 16, 5572-5581 (1997) [PubMed] [1IR3]

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J. Science 276, 955-960 (1997) [PubMed] [1AGW] [1FGI]

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism. Mohammadi M, Schlessinger J, Hubbard SR. Cell 86, 577-587 (1996) [PubMed] [1FGK]

Crystal structure of the tyrosine kinase domain of the human insulin receptor. Hubbard SR, Wei L, Ellis L, Hendrickson WA. Nature 372, 746-754 (1994) [PubMed] [1IRK]

*Co-corresponding author